Applied Biocatalysis   (436B1)

Academic year:

2019/2020.

Attendance requirements:

There are no requirements.

ECTS:

6

Study level:

Study programs:

Teachers:

Zoran M. Vujčić, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Radivoje M. Prodanović, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

—

Hours of instruction:

Weekly: four hours of lectures (4+0+0)

Goals:

Introducing students to the basic mechanisms of biocatalysis and stabilization of biocatalysts by chemical modification and immobilization with the aim of applying them in non-aqueous media, organic syntheses, pharmaceutical, chemical and food industries, biosensors, biofuel cells, enzyme-based logic circuits and nanobiotechnology.

Outcome:

Enabling students to use biocatalysts in real conditions in industry and in laboratories within scientific research.

Teaching methods:

Lectures, public presentation of the term papers.

Extracurricular activities:

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Coursebooks:

• Adrie J. J. Straathof, Patrick Adlercreutz: Applied Biocatalysis, Harwood Academic Publishers, 2000.
• Andreas S. Bommarius, Bettina R. Riebel: Biocatalysis - Fundamentals and Applications, Wiley-VCH, 2004.
• K. Drauz, H. Groeger, O.May: Enzyme Catalysis in Organic Synthesis, Wiley-VCH 2012.
• Selected papers.

Additional material:

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Lectures:

20 points (4 hours a week)

Syllabus:

1. Introduction to protein structure and biocatalysis.
2. Production and purification of biocatalysts.
3. Stability and kinetics of biocatalysts.
4. Chemical modifications of biocatalysts.
5. Immobilization of biocatalysts.
6. Biocatalysis in non-aqueous media.
7. Application of biocatalysts in syntheses and pharmaceutical industry.
8. Application of biocatalysts in food, textile and chemical industries.
9. Application of biocatalysts in biosensors and biofuel cells (batteries).
10. Application of biocatalysts in enzyme-based logic "circuits" and nanobiotechnology.

Semester papers:

20 points

Oral exam:

60 points