Mechanisms of Action of Physiologically Active Compounds   (454B1)

Academic year:

2019/2020.

Attendance requirements:

There are no requirements.

ECTS:

4

Study level:

Study program:

Teacher:

Milan R. Nikolić, Ph.D.
associate professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

—

Hours of instruction:

Weekly: two hours of lectures + two hours of labwork (2+0+2)

Goals:

The course is based on prior knowledge of signaling pathways and regulation of metabolism to understand their mutual connection and modulation capabilities of their functions by using drugs. The basic routes of administration, transport, distribution, and action of drugs (pharmacokinetics and pharmacodynamics) will be elaborated on the example of psychopharmacology, therapy of hyperlipidemia, hypertension, and diabetes, as well as chemotherapeutics. The final part of the course will briefly cover nanotechnologies and their applications in medicine.

Outcome:

Upon successful completion of the course, a student will be able to: independently and comprehensively considers the effects of biologically active substances (drugs), mechanisms of drug action and strategy of drug transport in the target tissues.

Teaching methods:

Lectures and experimental exercises.

Extracurricular activities:

—

Coursebooks:

Main coursebooks:

Drugs and controlled substances: information for students, Stacey Blachford and Kristine Krapp, Eds. 1st Edition, 2002; Gale Publishing.
Introduction to Drug Metabolism, G. Gordon Gibson and Paul Skett. 3rd Edition, 2001; Nelson Thornes Ltd. Publishing.
BRS Pharmacology, Gary C. Rosenfeld and David S. Loose. 4th edition, 1997; Lippincott Williams & Wilkins Publishing.

Supplementary coursebooks:

Power point presentation of lectures: see under additional materials.

Selected review papers.

Additional material:

http://www.chem.bg.ac.rs/~mnikolic

Lectures:

10 points (2 hours a week)

Syllabus:

The integration of signal transduction in the regulation of metabolism: general principles of physiologically active substances action; Ways of entry of drugs into the body: systems for drugs biotransport; Drug metabolism and factors influencing drugs action; Drugs for cardiovascular system; Psychopharmacology; Natural substances and drugs for reducing the content of lipids in the blood; Antidiabetic drugs and protein therapeutics; Malignant cells: principles of chemotherapeutics action; Molecular nanomedicine and nanorobots.

Labwork:

30 points (2 hours a week)

Syllabus:

Pleiotropic effects of physiologically active substances: determining the antioxidant potential of selected classes of drugs and herb extracts.

Oral exam:

60 points