Course code:
453B2		 Course name:
Biochemistry and Biophysics of Macromolecules

Academic year:

2024/2025.

Attendance requirements:

There are no requirements.

ECTS:

4

Study level:

graduate academic studies

Study program:

Biochemistry: 1. year, winter semester, elective (E53B2) course

Teacher:

Natalija Đ. Polović, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistant:

Jelica R. Milošević, Ph.D.
assistant with PhD, Faculty of Chemistry, Studentski trg 12-16, Beograd

Hours of instruction:

Weekly: two hours of lectures + two hours of labwork (2+0+2)

Goals:

The aim of this course is to give brief survey of knowledge of structure-function relationships of biomacromolecules and contemporary biochemical and biophysical techniques for structural and functional analysis of biomacromolecules.

Outcome:

At the end of this course, student will be able to understand structure-activity relationships of biomacromoleculs and to apply contemporary biochemical and biophysical techniques to analyse them.

Teaching methods:

Interactive lectures, laboratory work, seminars.

Extracurricular activities:

—

Coursebooks:

Main coursebooks:

  • C. Stan Tsai, Biomacromolecules: Introduction to Structure, Function and Informatics, Wiley, 2007.
  • Andrew D. Miller, Julian Tanner: Essentials of Chemical Biology: Structure and Dynamics of Biological Macromolecules, Wiley, 2008.

Supplementary coursebooks:

  • Selected research papers.

Additional material:

—

  Course activities and grading method

Lectures:

10 points (2 hours a week)

Syllabus:

  1. Introduction to biochemistry and biophysics of macromolecules.
  2. Structure of biomacromolecules (proteins, nucleic acids, polysaccharides).
  3. Biochemical and biophysical strategies in investigating structure-function relationships.
  4. Exploring structure and activity of biomacromolecules - selected techniques.
  5. Exploring interactions of biomacromolecules - selected techniques.
  6. Problem-based metodologies in biomacromolecular research.

Labwork:

30 points (2 hours a week)

Syllabus:

  1. Monitoring of structural transitions of proteins, nucleic acids and polysaccharides using biophysical techniques.
  2. Detection and determination of thermodynamic and kinetic parameters of protein-ligand interactions.
  3. Project-based lab work.

Semester papers:

30 points

Oral exam:

30 points