Course code:
422B1		 Course name:
Pathobiochemistry

Academic year:

2019/2020.

Attendance requirements:

402B1

ECTS:

8

Study level:

basic academic studies

Study program:

Biochemistry: 4. year, summer semester, compulsory course

Teacher:

Marija Đ. Gavrović Jankulović, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

Jelica R. Milošević, Ph.D.
assistant professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Isidora I. Protić Rosić, Ph.D.
teaching assistant, Faculty of Chemistry, Studentski trg 12-16, Beograd

Hours of instruction:

Weekly: four hours of lectures + four hours of labwork (4+0+4)

Goals:

The goal of this course is to broaden students’ knowledge of the pathological mechanisms responsible for the development of diseases. Students will study inborn and acquired disorders responsible for the development of diseases through examples. In order to help students understand the molecular basis of disorders, they will study the changes discovered at the molecular level (DNA, proteins) and at the cellular level, as well as the changes developed in the tissues and in the entire body. This approach to the study of pathological processes should help students understand and acquire novel knowledge of biological processes underlying normal and pathological conditions. Apart from the theoretical knowledge students will acquire in the lectures, they will also do some practical work which will enable them to acquire skills and become familiar with the methods applied in clinical practice for diagnosing and monitoring pathological conditions.

Outcome:

Comprehensive knowledge in the field of the molecular basis of pathological processes and the ability to carry out independent research.

Teaching methods:

Lectures, experimental work, term papers.

Extracurricular activities:

Preparing for experimental work. Preparing and writing a term paper.

Coursebooks:

Main coursebooks:

  • Carl A. Burtis, Edward R. Astwood: Tietz Fundamentals of Clinical Chemistry, 5th edition
  • William Marshall, Stephen K. Bangert: Clinical Chemistry, 5th edition
  • Tomas M. Devlin: Textbook of biochemistry with clinical correlations, 4th edition

Supplementary coursebooks:

  • Marija Gavrović-Jankulović: Selected chapters in Pathobiochemistry, Faculty of Chemistry, Belgrade
  • Olgica Nedić, Srdjan Stojanović: Biochemical processis in pathological metabolism, Faculty of Chemistry, Belgarde

Additional material:

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  Course activities and grading method

Lectures:

10 points (4 hours a week)

Syllabus:

  1. Amino acid metabolism disorders.
  2. Plasma protein disorders.
  3. Disorders of carbohydrate metabolism.
  4. Disorders of lipid and lipoprotein metabolism.
  5. Disorders of nucleotide metabolism. Disorders of microelements.
  6. Disorders of minerals. Disorders of vitamins.
  7. Disorders of erythrocytes and Hb. Disorders of porphyrin metabolism.
  8. Disorders of the hepatobiliary system.
  9. Electrolyte disorders. Disorders of the excretory system.
  10. Disorders of leukocytes and the immune system.
  11. Disorders of the gastrointestinal tract. Disorders of the respiratory system.
  12. Enzymes in clinical diagnostics.
  13. Hormone disorders.
  14. Oncology and tumor markers. Fibrosis.
  15. Biochemical tests in clinical medicine.

Labwork:

25 points (4 hours a week)

Syllabus:

  • Disorders of amino acid and protein metabolism
  • Disorders of carbohydrate metabolism (diabetes mellitus)
  • Disorders of lipid metabolism (cardiovascular diseases)
  • Electrolyte and mineral metabolism disorders (bone diseases)
  • Disorders of the metabolic processes in the liver (hepatobiliary diseases)
  • Disorders of heme anabolism and catabolism
  • Non-protein nitrogen compounds
  • The application of enzymes in clinical diagnostics
  • The teacher examines and signs students’ laboratory notebooks. Students return the glassware and equipment they have borrowed for the laboratory classes.

Semester papers:

5 points

Colloquia:

10 points

Oral exam:

50 points