Modern Structural Methods 2   (276H2)

Academic year:

2023/2024.

Attendance requirements:

There are no requirements.

ECTS:

10

Study level:

Study programs:

Teachers:

Slobodan M. Milosavljević, Ph.D.
professor emeritus, Faculty of Chemistry, Studentski trg 12-16, Beograd

Vele V. Tešević, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

—

Hours of instruction:

Weekly: five hours of lectures + three hours of study research work

Goals:

Students should get acquainted with the following areas of instrumental methods:

1. Multipulse 1D (¹H, ¹³C, ¹⁵N and ³¹P), 2D, 3D and 4D NMR methods, semi-solid state NMR (HR-MAS NMR) as well as their application.
2. Mass spectrometry (MS), Tandem mass spectrometry (MS/MS) and multistage mass spectrometry (MSⁿ) and MALDI imaging in biomedical sample analysis (Determination of protein structure. Analytical profiling of complex mixtures e.g. tissue).
3. Analytical profiling of complex mixtures, e.g. blood and urine samples.
4. Medicinal diagnostics.

Outcome:

Students will be trained for processing the recorded spectra and solving the structures of organic compounds using multipulsed NMR experiments and modern mass spectrometry methods. Moreover, students will be able to prepare and profiling samples of complex mixtures in various matrixes by advanced instrumental methods.

Teaching methods:

Lectures, colloquia and semester papers.

Extracurricular activities:

Guest lectures.

Coursebooks:

1. Slobodan Milosavljević: Strukturne instrumentalne metode
2. Vele Tešević: Osnove masene spektrometrije organskih jedinjenja
3. Ernö Pretsch, Philippe Bühlmann and Martin Badertscher: Structure determination of organic compounds, Tables of Spectral Data
4. L. D. Field, S. Sternhell, J. R. Kalman: Organic structures from spectra, fourth edition

Additional material:

—

Lectures:

0 points (5 hours a week)

Semester papers:

30 points

Colloquia:

30 points

Oral exam:

30 points

Study research work:

10 points (3 hours a week)