Course code:
171A2		 Course name:
Metals and Metal Complexes in Medicine

Academic year:

2023/2024.

Attendance requirements:

There are no requirements.

ECTS:

10

Study level:

doctoral academic studies

Study programs:

Chemistry: 1. year, winter semester, elective (E71H2) course

Chemistry: 1. year, winter semester, elective (E72H2) course

Chemistry: 2. year, winter semester, elective (E73H2) course

Chemistry: 2. year, winter semester, elective (E74H2) course

Biochemistry: 1. year, winter semester, elective (E71B2) course

Biochemistry: 1. year, winter semester, elective (E72B2) course

Biochemistry: 2. year, winter semester, elective (E74B2) course

Biochemistry: 2. year, winter semester, elective (E73B2) course

Teachers:

Tibor J. Sabo, Ph.D.

Sanja R. Grgurić Šipka, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

—

Hours of instruction:

Weekly: five hours of lectures + three hours of study research work

Goals:

Acquiring the students with the role of metals in biological systems and potential application of metals and metal complexes in medicine.

Outcome:

After this course students should be able to recognize the role of metals and metal complexes in biological systems and their potential applications in medicine.

Teaching methods:

Lectures, semester papers.

Extracurricular activities:

Visiting pharmaceutical companies.

Coursebooks:

Main coursebooks:

  • Metal Ions in Biological Systems. Ed. Sigel and Sigel

Supplementary coursebooks:

  • Papers from the journals

Additional material:

—

  Course activities and grading method

Lectures:

0 points (5 hours a week)

Syllabus:

I. Metal and metal ions in medicine. 1. Metals of main group of elements. Role and application as metalotherapeutics. 2. Transition metals, role and therapeutic potential. 3. Role and application of vanadium, silicon, gold, cobalt, arsen and bismuth.

II. 1. Application of metal complexes in medicine. 1. Contrast agens in diagnostic. 2. Cisplatin and related anticancer drugs. 3. Antitumor active trans-platinum compounds, polynuclear platinum drugs. 4. Ruthenium anticancer drugs. 5. Antitumor titanium compounds and related metallocenes. 6. Application of gold complexes in medicine. 7. Gallium and other main group metal compounds as antitumor agents. 8. Metal ion dependent antibiotics in chemotherapy. 9. Metal complexes in treatment of tropical deseas. 10. Metal complexes in nitrogen monoxide modulation.

Semester papers:

30 points

Oral exam:

70 points

Study research work:

0 points (3 hours a week)