Group for Synthetic Bio(techno)logy

Group members

• Jelena Radosavljević, PhD, Assistant Professor, University of Belgrade - Faculty of Chemistry
• Aleksa Savić, PhD student at UB-FC
• Marija Stefanović, MSc student at UB-FC

Research areas

1. Metagenome search for enzymatic activities that have applications in syntheses (MeMEAS project).
2. Application of machine learning/artificial intelligence to improve the activity of hydrolytic enzymes of interest for biotechnology and environmental protection (e.g. PET-degrading enzymes and enzymes that degrade polymeric pollutants).
3. Development of methodologies for monitoring the interactions of proteins that have a disordered structure with other proteins, using fluorescent (protein) markers.
4. Examination of critical protein fragments for the formation of ordered protein oligomers, e.g. virus-like particles.

Publications

• Andjelkovic Ljubica D, Jeremic Dejan A, Milenkovic Milica R, Radosavljevic Jelena, Vulic Predrag J, Pavlovic Vladimir B, Manojlovic Dragan D, Nikolic Aleksandar: Synthesis, characterization and in vitro evaluation of divalent ion release from stable NiFe₂O₄, ZnFe₂O₄ and core-shell ZnFe₂O₄@NiFe₂O₄ nanoparticles. CERAMICS INTERNATIONAL, (2020), Vol. 46 No. 3, pp. 3528-3533.
• Martinovic Biljana, Jelic Ivana V, Rikalovic Milena G, Sljivic-Ivanovic Marija Z, Radosavljevic Jelena, Kostic Aleksandar, Adzemovic Mesud R: Comparison of Air Pollution in the Working Environment During in Site Treatment of Infectious Medical Waste by Convertor and Autoclave Sterilization. FRESENIUS ENVIRONMENTAL BULLETIN, (2020), Vol. 29 No. 4, pp. 2160-2165.
• Machackova Katerina, Mlcochova Kvetosalva, Potalitsyn Pavlo, Hankova Katerina, Socha Ondrej, Budesinsky Milos, Muydalo Anja, Lepsik Martin, Cernekova Michaela, Radosavljevic Jelena, Fabry Milan, Mitrova Katerian, Chrudinova Martina, Lin Jingjing, Yurenko Yevgen, Hobza Pavel, Selicharova Irena, Zakova Lenka, Jiracek Jiri: Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. JOURNAL OF BIOLOGICAL CHEMISTRY, (2019), Vol. 294 No. 46, pp. 17371-17382.
• Prodic Ivana, Smiljanic Katarina T, Simovic Ana, Radosavljevic Jelena, Cirkovic-Velickovic Tanja D: Thermal Processing of Peanut Grains Impairs Their Mimicked Gastrointestinal Digestion While Downstream Defatting Treatments Affect Digestomic Profiles. FOODS, (2019), Vol. 8 No. 10.
• Pompach Petr, Viola Cristina M, Radosavljevic Jelena, Lin Jingjing, Jiracek Jiri, Brzozowski Andrzej M, Selicharova Irena: Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2. FRONTIERS IN ENDOCRINOLOGY, (2019), Vol. 10.
• Machackova Katerina, Chrudinova Martina, Radosavljevic Jelena, Potalitsyn Paulo, Krizkova Kvetoslava, Fabry Milan, Selicharova Irena, Collinsova Michaela, Brzozowski Andrzej M, Zakova Lenka, Jiracek Jiri: Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation. BIOCHEMISTRY, (2018), Vol. 57 No. 16, pp. 2373-2382.

Partners

• Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Czech Republic
  https://www.uochb.cz/en
• University of Belgrade - Institute of Molecular Genetics and Genetic Engineering, Serbia
  https://www.imgge.bg.ac.rs/lat/
• University of Belgrade - Institute for Multidisciplinary Research, Serbia
  https://www.imsi.bg.ac.rs/en/home/
• University of Belgrade - Faculty of Pharmacy, Serbia
  http://www.pharmacy.bg.ac.rs/en/
• ePlus Systems Ltd, Serbia
  https://www.eplus.systems/

Projects

• "Metagenome Mining of Enzymatic Activity for Synthetic Applications"
  coordinator: Jelena Radosavljević, PhD, Assistant Professor
  (Serbia - United Kingdom)
• 2020-2022: PoC-5894 "Production of protein, a potential marker of linden allergy"
  financier: Fund for Innovation Activity of the Republic of Serbia,
  coordinator: Jelena Radosavljević, PhD, Assistant Professor
• 2020-2022: "Development of tests for the detection of capsid proteins of SARS Cov-2 virus in biological fluids of patients with COVID19 - CAPSIDO"
  financed by the Science Fund of the Republic of Serbia within the Special Program of Research for COVID19,
  coordinator: prof. Tanja Ćirković Veličković, PhD, full professor and corresponding member of SASA
• 2020-2022: "Late Embryogenesis Abundant Proteins: Structural Characterization and Interaction with α-Synuclein - LEAPSin-SCI"
  financier: Science Fund of the Republic of Serbia,
  project participant: Jelena Radosavljević, PhD, Assistant Professor
• 2020-2021: "Sustainable production of serological IgG test for SARS CoV-2"
  financed by UNDP/WHO,
  coordinator: Tanja Ćirković Veličković PhD, full professor and corresponding member of SASA
• COST action CA18227: "The Core Outcome Measures for Food Allergy"
  member of the Management Committee: Tanja Ćirković Veličković, PhD, full professor and corresponding member of SASA,
  Deputy Member of the Management Committee: Jelena Radosavljević, PhD, Assistant Professor