Group Members

Research Area

Our research group fuses three different but complementary areas of chemistry: inorganic, bioionorganic and medicinal. The main objective of the research is to develop novel tumor-inhibiting metal complexes and organometallic compounds. All projects undertaken in our group start with the preparation of organic ligands or derivatives of naturally occurring compounds, and corresponding coordination or organometallic compounds followed with thoroughly characterization by means of various analytical methods. The potential of inhibiting cancer cell growth is determined in cell culture tests and investigations of modes of action of compounds are performed in cooperation with the Institute of Oncology and Radiology of Serbia, Faculty of Medicinal science University of Kragujevac and Faculty of Medicine University of Belgrade. Pharmacokinetic and pharmacodynamic parameters are determined at University of Belgrade - Faculty of Pharmacy and Faculty of Medicine University of Banja Luka. Apart from the fundamental research performed in the area of bioinorganic chemistry, the research group has also been working on the development of different product, e.g. bio-inspired baby wipes, aimed for potential commercialization.

Equipment Used by the Group in its Work

  • NMR 500 MHz - Bruker Avance III
  • NMR 400 MHz - Varian / Agilent
  • THERMO Scientific Nicolet 6700 FT-IR Spectrometer
  • Agilent 7890A - 5975C inert XL EI CI
  • Agilent 7890A (GC)
  • Elementar Vario EL III
  • BRUKER MICROTOF II + Agilent 1200 HPLC
  • Camag HPTLC
  • Thermo Scientific Delta V advantage IRMS
  • Apparatus for ultra clean water TKA08.1205-ST
  • Waters HPLC system
  • DIONEX ICS 3000
  • Cintra 6 spectrophotometer
  • Agilent Infinity 1260 HPLC
  • Bioreactor BIOSTAT Bplu 2L DW 230V
  • JASCO J-815 CD spectrophotometer
  • Hybrid mass spectrometer LTQ Orbitrap XL

Publications

  1. Dragana Stanic-Vucinic, Stefan Nikolic, Katarina Vlajic, Mirjana Radomirovic, Jelena Mihailovic, Tanja Cirkovic Velickovic, Sanja Grguric-Sipka, The interactions of the ruthenium(II)-cymene complexes with lysozyme and cytochrome c, J Biol Inorg Chem (2020) 25:253.
  2. Marijana Pavlović, Ana Tadić, Nevenka Gligorijević, Jelena Poljarević, Tamara Petrović, Biljana Dojčinović, Aleksandar Savić, Siniša Radulović, Sanja Grgurić-Šipka, Sandra Aranđelović, Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells, J Inorg Biochem (2020) 210: 111155.
  3. János P. Mészáros, Jelena M. Poljarević, István Szatmari, Oszkár Csuvik, Ferenc Fülöp, Norbert Szoboszlai, Gabriella Spengler, Éva A. Enyedy, An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes, Dalton Trans. (2020) 49: 7977.
  4. Biljana Tubić, Vladimir Dobričić, Jelena Poljarević, Aleksandar Savić, Tibor Sabo, Bojan Marković, Estimation of passive gastrointestinal absorption and membrane retention using PAMPA test, quantitative structure-permeability and quantitative structure-retention relationship analyses of ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid and 1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid derivatives, J. Pharmaceutical and Biomedical Analysis (2020) 184: 113213.
  5. Ljiljana E. Mihajlović-Lalić, Dalibor Stanković, Jelena Poljarević, Tibor J. Sabo, Dragan Manojlović, Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands, J. Electrochem. Soc. (2018) 165: G123.

Partners

Projects

  • 2011-2016: "Rational Design and Synthesis of Bioactive and Coordination Compounds and Functional Materials Relevant for (bio)Nanotechnology" (172035)
    funded by: Ministry of Science and Technological Development (Belgrade, Serbia),
    principal investigator: Dr. Aleksandar Nikolić
  • 2020-2021: "Baby wet wipes pioneer innovation: skin- and eco-friendly sustainability concept" (PoC ID: 5087)
    funded by: Innovation Fund of the Republic of Serbia,
    principal investigator: Dr. Ljiljana Mihajlović-Lalić