Group Members
- dr Sanja Grgurić-Šipka, full professor
- dr Tibor Sabo, full professor
- Tamara Petrović, graduate researcher
- Milica Ćalić, teaching assistant
Research Area
Our research group fuses three different but complementary areas of chemistry: inorganic, bioionorganic and medicinal. The main objective of the research is to develop novel tumor-inhibiting metal complexes and organometallic compounds. All projects undertaken in our group start with the preparation of organic ligands or derivatives of naturally occurring compounds, and corresponding coordination or organometallic compounds followed with thoroughly characterization by means of various analytical methods. The potential of inhibiting cancer cell growth is determined in cell culture tests and investigations of modes of action of compounds are performed in cooperation with the Institute of Oncology and Radiology of Serbia, Faculty of Medicinal science University of Kragujevac and Faculty of Medicine University of Belgrade. Pharmacokinetic and pharmacodynamic parameters are determined at University of Belgrade - Faculty of Pharmacy and Faculty of Medicine University of Banja Luka. Apart from the fundamental research performed in the area of bioinorganic chemistry, the research group has also been working on the development of different product, e.g. bio-inspired baby wipes, aimed for potential commercialization.
Equipment Used by the Group in its Work
- NMR 500 MHz - Bruker Avance III
- NMR 400 MHz - Varian / Agilent
- THERMO Scientific Nicolet 6700 FT-IR Spectrometer
- Agilent 7890A - 5975C inert XL EI CI
- Agilent 7890A (GC)
- Elementar Vario EL III
- BRUKER MICROTOF II + Agilent 1200 HPLC
- Camag HPTLC
- Thermo Scientific Delta V advantage IRMS
- Apparatus for ultra clean water TKA08.1205-ST
- Waters HPLC system
- DIONEX ICS 3000
- Cintra 6 spectrophotometer
- Agilent Infinity 1260 HPLC
- Bioreactor BIOSTAT Bplu 2L DW 230V
- JASCO J-815 CD spectrophotometer
- Hybrid mass spectrometer LTQ Orbitrap XL
Publications
- Dragana Stanic-Vucinic, Stefan Nikolic, Katarina Vlajic, Mirjana Radomirovic, Jelena Mihailovic, Tanja Cirkovic Velickovic, Sanja Grguric-Sipka, The interactions of the ruthenium(II)-cymene complexes with lysozyme and cytochrome c, J Biol Inorg Chem (2020) 25:253.
- Marijana Pavlović, Ana Tadić, Nevenka Gligorijević, Jelena Poljarević, Tamara Petrović, Biljana Dojčinović, Aleksandar Savić, Siniša Radulović, Sanja Grgurić-Šipka, Sandra Aranđelović, Synthesis, chemical characterization, PARP inhibition, DNA binding and cellular uptake of novel ruthenium(II)-arene complexes bearing benzamide derivatives in human breast cancer cells, J Inorg Biochem (2020) 210: 111155.
- János P. Mészáros, Jelena M. Poljarević, István Szatmari, Oszkár Csuvik, Ferenc Fülöp, Norbert Szoboszlai, Gabriella Spengler, Éva A. Enyedy, An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes, Dalton Trans. (2020) 49: 7977.
- Biljana Tubić, Vladimir Dobričić, Jelena Poljarević, Aleksandar Savić, Tibor Sabo, Bojan Marković, Estimation of passive gastrointestinal absorption and membrane retention using PAMPA test, quantitative structure-permeability and quantitative structure-retention relationship analyses of ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid and 1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid derivatives, J. Pharmaceutical and Biomedical Analysis (2020) 184: 113213.
- Ljiljana E. Mihajlović-Lalić, Dalibor Stanković, Jelena Poljarević, Tibor J. Sabo, Dragan Manojlović, Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands, J. Electrochem. Soc. (2018) 165: G123.
Partners
- Sandra Aranđelović, Institute for Oncology and Radiology of Serbia
https://www.ncrc.ac.rs/ - Nevenka Gligorijević, Institute for Oncology and Radiology of Serbia
https://www.ncrc.ac.rs/ - Ivan Spasojević, Institute for Multidisciplinary Research
http://www.imsi.bg.ac.rs/sr/ - Vladimir Jakovljević, Faculty of Medicinal science University of Kragujevac
http://www.medf.kg.ac.rs/ - Ivan Srejović, Faculty of Medicinal science University of Kragujevac
http://www.medf.kg.ac.rs/ - Bojan Marković, University of Belgrade - Faculty of Pharmacy
http://www.pharmacy.bg.ac.rs/ - Vladimir Savić, University of Belgrade - Faculty of Pharmacy
http://www.pharmacy.bg.ac.rs/ - Biljana Tubić, Faculty of Medicine - Department of Pharmacy, University of Banja Luka
https://www.unibl.org/sr/clanice/fakulteti/medicinski-fakultet - The agency for Medicinal Products and Medicinal Devices Banja Luka, Bosnia and Herzegovina
http://www.almbih.gov.ba/ - Sonja Misirlić-Denčić, Faculty of Medicine University of Belgrade
http://med.bg.ac.rs/ - Bernhard K. Keppler Institute for Inorganic Chemistry, University of Vienna, Austria
https://anorg-chemie.univie.ac.at/ - Vladimir B. Arion, Institute for Inorganic Chemistry, University of Vienna, Austria
https://anorg-chemie.univie.ac.at/ - Gilles Gasser, Université Paris Sciences et Lettres, France
https://psl.eu/en - Ulrich Schatzschneider, Julius-Maximilians-Universität Würzburg, Germany
https://www.uni-wuerzburg.de/en/home/ - George Psomas, Aristotle University of Thessaloniki, Greece
https://www.auth.gr/en/uni - Luigi Messori, Department of Chemistry, University of Florence, Italy
https://www2.chim.unifi.it/changelang-eng.html - Éva Anna Enyedy, University of Szeged, Department for Inorganic and Analytical Chemistry, Hungary
http://www2.sci.u-szeged.hu/chem/angol/kemia.php?ID=23
Projects
- 2011-2016: "Rational Design and Synthesis of Bioactive and Coordination Compounds and Functional Materials Relevant for (bio)Nanotechnology" (172035)
funded by: Ministry of Science and Technological Development (Belgrade, Serbia),
principal investigator: Dr. Aleksandar Nikolić - 2020-2021: "Baby wet wipes pioneer innovation: skin- and eco-friendly sustainability concept" (PoC ID: 5087)
funded by: Innovation Fund of the Republic of Serbia,
principal investigator: Dr. Ljiljana Mihajlović-Lalić