Applied Organic Chemistry   (234A2)

Academic year:

2023/2024.

Attendance requirements:

(201A2 + 202A2) / (201B2 + 202B2)

ECTS:

8

Study level:

Study programs:

Teacher:

Deana B. Andrić, Ph.D.
associate professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

—

Hours of instruction:

Weekly: four hours of lectures + two hours of labwork (4+0+2)

Goals:

The main goal of this course is to help students acquire the relevant knowledge of the synthesis reactions which are used in industry, particularly in the synthesis of drugs. The course also introduces them to the structure, application and synthesis of various classes of organic compounds, both simple and complex, which have practical applications and which are industrially produced.

Outcome:

Enabling students to successfully do their professional tasks upon the completion of their studies in education, industry and research work. Furthermore, this course provides the foundation necessary for postgraduate studies.

Teaching methods:

The lectures are held with the use of a video beam projector and a visualization program. The contents of the entire course and the supplementary material are available to students in an electronic form.

Extracurricular activities:

—

Coursebooks:

Main coursebooks:

1. Organic Process Research & Development, ACS Publications, 1997-2007, relevant papers http://pubs.acs.org/journals/oprdfk/index.html
2. W. Carruthers, Iain Coldham: Modern Methods of Organic Synthesis, 4th Edition, Cambridge University Press, 2004.
3. Original patent literature
4. H. U. Blaser, E. Schidt (Eds): Asymmetric Catalysis on Industrial Scale, Wiley-VCH, 2004.
5. Daniel Lednicer: The Organic Chemistry of Drug Synthesis, Vol. 1- 7 Wiley-Interscience, 1977-2007.
6. Encyclopedia of Biological Chemistry, Elsevier, 2004.
7. Burger's Medicinal Chemistry and Drug Discovery, J. Wiley & Sons, 2007.
8. Annual Reports in Medicinal Chemistry, Elsevier, Vol. 33-40.
9. George A. Burdock: Fenaroli’s Handbook of Flavor Ingredients, Fourth Edition, CRC Press, 2001.
10. Patrick Etiévant, Andrée Voilley (Eds): Flavour in Food, Woodhead Publishing, 2006.
11. Ullmann's Encyclopedia of Industrial Chemistry, J. Wiley&Sons, 2007.
12. Hilda Butler: Poucher's Perfumes, Cosmetics and Soaps, 10^th Edition, Springer-Verlag
13. Thomas J. J. Müller, Uwe H. F. Bunz (Eds): Functional Organic Materials Syntheses, Strategies and Applications, Wiley-VCH, 2007.
14. Jonathan W. Steed, David R. Turner, Karl J. Wallace: Core Concepts in Supramolecular Chemistry and Nanochemistry, J. Wiley & Sons, 2007.

Supplementary coursebooks:

• Willy Herbst, Klaus Hunger: Industrial Organic Pigments, Third Edition. Wiley-VCH, 2004.

Additional material:

—

Lectures:

0 points (4 hours a week)

Syllabus:

I. IMPORTANT CLASSES OF ORGANIC REACTIONS WHICH HAVE LARGE-SCALE APPLICATION IN PHARMACEUTICAL INDUSTRY

A short overview of important reactions used to form a new C-C bond and a new C-N bond. A short overview of various methods of oxidation, reduction, halogenation, etc. with a special focus on the current methods.

II. SELECTED CHAPTERS OF APPLIED ORGANIC CHEMISTRY

1. Important classes of drugs: structure and synthesis. 2. Food additives: preservatives, colors, emulsifiers. 3. Cosmetics - basic classification, use and structures. 4. Agrochemicals - classification by structure and use. 5. Organic polymers - basics, classification, structure. 6. Composite materials - basics, classification, structure, application. 7. Nanomaterials - basics, classification, structure, application. 8. Dyes, pigments, indicators - basics, classification, structure, application. 9. Organic light-emitting diodes, organic conductors, organic transistors - basics, classification, structure. 10. Liquid crystals - basics, classification, structure. 11. Organic light sources - chemiluminescence - basics. 12. Materials for chiral chromatography - basics. 13. Explosives and rocket fuels - basics, classification, structure, application, basics of synthesis. 14. The application of pure enzymes (immobilized or in a solution) in pharmaceutical industry - concepts, classification, structure. 15. Detergents - basics, classification, structure.

III. INDUSTRIAL METHODS FOR SYNTESIS AND CONVERSION OF SIMPLE ORGANIC CHEMICALS

1. Alkenes, dienes, polyenes. 2. Alkynes. 3. Products formed from carbon monoxide. 4. Alcohols. 5. Vinyl halides and derivatives. 6. Components of polyamides. 7. Aromates.

Note: Students have to attend the lectures regularly in order to qualify for the progress tests and the final exam.

Labwork:

0 points (2 hours a week)

Colloquia:

45 points

Remarks:

Three progress tests are organized and they are mostly of consultative nature.

Written exam:

55 points

Remarks:

Students do the fourth progress test and that test is their final exam.