Course code:
1132A		 Course name:
Chemistry of Bioelements

Academic year:

2012/2013.

Attendance requirements:

1102A / 1102B

ECTS:

6

Study level:

basic academic studies

Study programs:

Chemistry: 3. year, summer semester, elective (1IP3A) course

Biochemistry: 3. year, summer semester, elective (1IP3B) course

Chemistry Teacher: 3. year, summer semester, elective (1IP3A) course

Teacher:

Sanja R. Grgurić Šipka, Ph.D.
full professor, Faculty of Chemistry, Studentski trg 12-16, Beograd

Assistants:

—

Hours of instruction:

Weekly: four hours of lectures (4+0+0)

Goals:

The main goal of this course is for students to learn about the chemistry of bioelements. Within previous courses students were acquainted with physical and chemical properties of elements and their compounds. Here the emphasis is placed on their biological role (manifestation and role in the organism). Students will also learn about metal compounds used in medicine.

Outcome:

It is expected that students expand their knowledge of chemistry of bioelements, to understand which elements in which form is present in the body, as well as how electronic configuration of the element determines its physiological properties.

Teaching methods:

Lectures, seminars.

Extracurricular activities:

—

Coursebooks:

Main coursebooks:

  • Đenana Miodragović, script (for internal use), Book in prepararion

Supplementary coursebooks:

  • Wolfgang Kaim, Brigitte Schwederski: Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Wiley, Chichester, 2006.
  • Robert R. Crichton: Biological Inorganic Chemistry, an Introduction, Elsevier, Amsterdam, 2008.

Additional material:

—

  Course activities and grading method

Lectures:

5 points (4 hours a week)

Syllabus:

1. Position of bioelements in the periodic table of elements. Hydrogen and the nucleosynthesis of lighter elements (the Big Bang theory). Hydrogenases. Elements of the first group of the periodic table of elements: Li (lithium compounds in medicine, lithium and viruses); Na and K (role, transport through membranes, interactions with ionophores).

2. Elements of the second group of periodic table of elements: Mg (applications in medicine, Mg2 + as a cofactor, Mg-biomolecules), Ca (manifestations in the body, the role of vitamin D in calcium absorption). Elements of the fourteenth group of the periodic table of elements: C (inorganic compounds of carbon, bicarbonate buffer, introduction to organometallic chemistry - Vitamin B12).

3. Test.

4. Elements of the fifteenth group of the periodic table of elements: N (NO-role in the organism, nitrogen cycle, nitrogenases) and P (manifestations, phosphates buffer, ATP and related compounds, glycerophosphoipides).

5. Elements of sixteen group of the periodic table of elements: O (Fenton reaction, oxygen carriers - the active sites of hemoglobin, hemerythrin and  hemocuanin) and S (sulfur ligands containing, iron-sulfur proteins) Se.

6. Test.

7. Elements of the seventeenth group of the periodic table of elements (F, Cl, I - manifestations, the role and the importance in the body). Elements of the twelfth group of the periodic table of elements Zn (applications in medicine; examples of hydrolytic enzymes with zinc in the active site).

8. Transition elements (biomolecules containing V, Cr, Mn or Fe).

9. Transition elements (biomolecules containing Co, Ni Cu and Mo).

10. Diseases caused by the disruption of biometals homeostasis. Application of chelate ligands in the treatment of pathological disfunctions caused by the biometals concentration disorder.

11. Test.

12-15. Presentation of seminars.

Semester papers:

15 points

Colloquia:

30 points

Written exam:

50 points