[Hideyuki Inui]

Prof. Hideyuki Inui

Biosignal Research Center, Kobe University, Japan

Uptake mechanism of persistent organic pollutants by plants and its application to phytoremediation and crop safety

Prof. Inui completed his Ph.D. in Graduate School of Science and Technology, Kobe University, Japan in 1999. His research interest lies in uptake, transport, and metabolism of persistent organic pollutants in plants and its metabolism by mammalian xenobiotic metabolizing enzymes. He has been working as Associate Professor in Biosignal Research Center, Kobe University from 2016 after Lecturer and Assistant Professor in Kobe University from 1999. During his working carrier he researched basic sciences on remediation of organic pollutants using plants and clarification of metabolic fates of them in mammals and environment. He joined to Laboratory of Plant Biology in Rockefeller University, USA to develop biomonitoring plants that inform contamination of dioxins and endocrine disruptors in the environment in 2001-2002. Prof. Inuireceivedmany types of grants from Ministry of Agriculture, Forestry and Fisheries of Japan, Ministry of Education, Culture, Sports, Science and Technology of Japan, and Japan Society for Promotion of Science (JSPS). He became a host researcher for JSPS invitational fellow from Serbia and JSPS postdoctoral fellow from Bulgaria. He has published almost50research articlesin high impact journals and 15 book chapters. Prof. Inui is also working as a standing councillor of Japan Society of Pesticide Science and an expert committee member of Food Safety Commission in Cabinet Office, Government of Japan.

Selected Publications
  1. Goto, E., Haga, Y., Kubo, M., Itoh, T., Kasai, C., Shoji, O., Yamamoto, K., Matsumura, C., Nakano, T., Inui, H.*, Metabolic enhancement of 2,3',4,4',5-pentachlorobiphenyl (CB118) using cytochrome P450 monooxygenase isolated from soil bacterium under the presence of perfluorocarboxylic acids (PFCAs) and the structural basis of its metabolism, Chemosphere, 210, 376-383, 2018
  2. Beškoski, P.V.*, Yamamoto, A., Nakano, T., Yamamoto, K., Matsumura, C., Motegi, M.,Beškoski, L., and Inui, H.*, Defluorination of perfluoroalkyl acids is followed by production of monofluorinated fatty acids, Science of the Total Environment, 636, 355-359, 2018
  3. Fukushi, K.*, Fujita, Y., Nonogaki, J., Tsujimoto, J-i., Hattori,, T., Inui, H.*, Beškoski, V. P., Hotta, H., Hayashi, M., Nakano, T., Capillary zone electrophoresis determination of fluoride in seawater using transient isotachophoresis, Analytical and Bioanalytical Chemistry, 410, 1825-1831, 2018
  4. Navrátilová, V., Paloncýová, M., Berka, K., Mise, S., Haga, Y., Matsumura, C., Sakaki, T., Inui, H.*, Otyepka, M.*, Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants, Biochimica et Biophysica Acta General Subjects, 1861, 2852-2860, 2017
  5. Beškoski, P.V.*, Yamamoto, K., Yamamoto, A., Okamura, H., Hayashi, M., Nakano, T., Matsumura, C., Fukushi, K., Wada, S., and Inui, H.*, Distribution of perfluoroalkyl compounds in Osaka Bay and coastal waters of Western Japan, Chemosphere, 170, 260-265, 2017
  6. Mise, S., Haga, Y., Itoh, T., Kato, A., Fukuda, I., Goto, E., Yamamoto, K., Yabu, M., Matsumura, C., Nakano, T., Sakaki, T., and Inui, H.*, Structural determinants for the position of 2,3',4,4',5-pentachlorobiphenyl (CB118) hydroxylation by mammalian cytochrome P450 monooxygenases, Toxicological Sciences, 152(2), 340-348, 2016, Selected for the cover page
  7. Yamazaki, K., Tsuruta, H. and Inui, H.*, Different uptake pathways between hydrophilic and hydrophobic compounds in lateral roots of Cucurbita pepo, Journal of Pesticide Science, 40(3), 99-105, 2015
  8. Inui, H.*, Hirota,M., Goto, J., Yoshihara, R., Kodama, N., Matsui, T., Yamazaki, K., and Eun, H., Zinc finger protein genes from Cucurbita pepo are promising tools for conferring non-Cucurbitaceae plants with ability to accumulate persistent organic pollutants, Chemosphere, 123, 48-54, 2015
  9. Yoshihara, R., Matsuo, S., Iwata, T., and Inui, H.*, Effect of amending soil with organic acids on perylene uptake into Cucurbita pepo, Journal of Pesticide Science, 39(3), 162-164, 2014
  10. Inui, H.*, Itoh, T., Yamamoto, K., Ikushiro, S.-I., and Sakaki, T., Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls, International Journal of Molecular Sciences, 15(8), 14044-14057, 2014

(* = Corresponding author)

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